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Congenital anomalies of the kidney and urinary tract genetics in mice and men
Author(s) -
Caruana Georgina,
Bertram John F.
Publication year - 2015
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12402
Subject(s) - medicine , urinary system , kidney , kidney development , disease , kidney disease , genetics , gene , bioinformatics , pathology , biology , embryonic stem cell
The most common cause of paediatric end‐stage kidney disease results from congenital anomalies of the kidney and urinary tract ( CAKUT ). Genetic manipulation in mice has provided insight into the developmental events that give rise to the broad spectrum of malformations associated with CAKUT . Despite the increase in the number of identified CAKUT ‐causing genes, the underlying genetic cause for the majority of patients with CAKUT remains unknown. In this mini‐review, we provide an overview of the genetic causes of CAKUT based on current mouse mutant models, as well as next‐generation sequencing approaches in humans that are helping to bridge the gaps in our understanding.