Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in J apanese individuals

Aim Various loci and genes that confer susceptibility to coronary artery disease ( CAD ) have been identified in C aucasian populations by genome‐wide association studies ( GWAS s). The aim of the present study was to examine a possible association of chronic kidney disease ( CKD ) with 29 polymorphisms previously identified as susceptibility loci for CAD by meta‐analyses of GWASs . Methods The study population comprised 2247 J apanese individuals, including 1588 subjects with CKD [estimated glomerular filtration rate ( eGFR ) of <60 mL min −1 1.73 m −2 ] and 659 controls ( eGFR of ≥90 mL min −1 1.73 m −2 ). The genotypes for 29 polymorphisms of 28 candidate genes were determined. Results The χ 2 test revealed that rs4845625 ( T → C ) of IL6R , rs4773144 ( A → G ) of COL4A1 , rs9319428 ( G→A ) of FLT1 , and rs46522 ( T → C ) of UBE2Z were significantly ( P  < 0.05) related to CKD . Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and dyslipidaemia revealed that rs4845625 of IL6R ( P  = 0.0008; dominant model; odds ratio, 1.49), rs4773144 of COL4A1 ( P  = 0.0252; dominant model; odds ratio, 1.28), and rs9319428 of FLT1 ( P  = 0.0260: additive model; odds ratio, 0.77) were significantly associated with CKD . The serum concentration of creatinine was significantly ( P  = 0.0065) greater and eGFR was significantly ( P  = 0.0009) lower in individuals with the TC or CC genotype of IL6R than in those with the TT genotype. Conclusion The rs4845625 of IL6R may be a susceptibility locus for CKD in J apanese individuals.