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Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in J apanese individuals
Author(s) -
Horibe Hideki,
Fujimaki Tetsuo,
Oguri Mitsutoshi,
Kato Kimihiko,
Matsuoka Reiko,
Abe Shintaro,
Tokoro Fumitaka,
Arai Masazumi,
Noda Toshiyuki,
Watanabe Sachiro,
Yamada Yoshiji
Publication year - 2015
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12381
Subject(s) - medicine , association (psychology) , polymorphism (computer science) , kidney disease , receptor , gene , immunology , genetics , genotype , biology , philosophy , epistemology
Aim Various loci and genes that confer susceptibility to coronary artery disease ( CAD ) have been identified in C aucasian populations by genome‐wide association studies ( GWAS s). The aim of the present study was to examine a possible association of chronic kidney disease ( CKD ) with 29 polymorphisms previously identified as susceptibility loci for CAD by meta‐analyses of GWASs . Methods The study population comprised 2247 J apanese individuals, including 1588 subjects with CKD [estimated glomerular filtration rate ( eGFR ) of <60 mL min −1 1.73 m −2 ] and 659 controls ( eGFR of ≥90 mL min −1 1.73 m −2 ). The genotypes for 29 polymorphisms of 28 candidate genes were determined. Results The χ 2 test revealed that rs4845625 ( T → C ) of IL6R , rs4773144 ( A → G ) of COL4A1 , rs9319428 ( G→A ) of FLT1 , and rs46522 ( T → C ) of UBE2Z were significantly ( P < 0.05) related to CKD . Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and dyslipidaemia revealed that rs4845625 of IL6R ( P = 0.0008; dominant model; odds ratio, 1.49), rs4773144 of COL4A1 ( P = 0.0252; dominant model; odds ratio, 1.28), and rs9319428 of FLT1 ( P = 0.0260: additive model; odds ratio, 0.77) were significantly associated with CKD . The serum concentration of creatinine was significantly ( P = 0.0065) greater and eGFR was significantly ( P = 0.0009) lower in individuals with the TC or CC genotype of IL6R than in those with the TT genotype. Conclusion The rs4845625 of IL6R may be a susceptibility locus for CKD in J apanese individuals.