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Effects of endothelial nitric oxide synthase gene on end stage renal disease progression in autosomal dominant polycystic kidney disease
Author(s) -
Xue Cheng,
Zhou Chenchen,
Sun Lijun,
He Liangliang,
Xu Chenggang,
Dai Bing,
Mei Changlin
Publication year - 2014
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12310
Subject(s) - medicine , enos , autosomal dominant polycystic kidney disease , odds ratio , allele , end stage renal disease , gene polymorphism , gastroenterology , genotype , polycystic kidney disease , kidney disease , endocrinology , asymmetric dimethylarginine , meta analysis , disease , nitric oxide , nitric oxide synthase , genetics , biology , gene , amino acid , arginine
Aim To investigate whether endothelial nitric oxide synthase (eNOS) gene associate with the progression of autosomal dominant polycystic kidney disease (ADPKD). Methods Databases of EMBASE , Pubmed, ISI , O vid Database, C ochrane library and C hina National Knowledge Infrastructure were all searched. Associated studies about eNOS polymorphisms and ADPKD were analyzed by meta‐analysis. Results A total of 11 studies with Glu298Asp and 4b/a polymorphisms were included. A allele of the 4b/a polymorphism increased the risk of end stage renal disease ( ESRD) in ADPKD (odds ratio ( OR) = 1.85, 95% confidence interval ( CI) 1.17–2.94, P = 0.009). However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk ( OR = 0.77, 95% CI 0.55–1.08, P = 0.13) nor affected the hypertension risk ( OR = 1.04, 95% CI 0.66–1.66, P = 0.86). The GG phenotype carriers had later ESRD age compared with the T allele of Glu298Asp polymorphism ( WMD = 2.39; 95% CI 1.32–3.46; P < 0.0001). Significant association was also found in C aucasians ( WMD = 2.41; 95% CI 1.18–3.64; P = 0.0001). Subgroup analysis by gender indicated GG genotype carriers had older age of ESRD than T allele carriers in males ( WMD = 4.51; 95% CI 3.95–5.08; P = 0.00001), but not in females. Conclusions GG genotype of the Glu298Asp variant slowed the ESRD progression in ADPKD , while a allele carriers of the 4b/a variant increased the risk of ESRD . Variants of eNOS gene might play different roles in the ESRD progression in ADPKD .