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Proliferative glomerulonephritis with monoclonal immunoglobulin A light‐chain deposits in the renal allograft
Author(s) -
Setoguchi Kiyoshi,
Kawashima Yoichiro,
Tokumoto Tadahiko,
Toma Hiroshi,
Mizoguchi Shogo,
Horita Shigeru,
Yamaguchi Yutaka,
Tanabe Kazunari
Publication year - 2014
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12251
Subject(s) - medicine , immunoglobulin light chain , glomerulonephritis , monoclonal antibody , monoclonal , antibody , immunoglobulin a , immunology , immunoglobulin g , kidney
We herein describe the unique case of a 59‐year‐old man who underwent living kidney transplantation for IgA nephropathy ( IgAN ) and developed progressive kidney failure associated with the appearance of proliferative glomerulonephritis. An early protocol biopsy revealed recurrent IgAN with mesangial IgA2 deposits restricted to a single immunoglobulin λ light‐chain isotype. Despite treatment with tonsillectomy and rituximab, the patient eventually lost his allograft 31 months after transplantation. Serum electrophoresis showed a monoclonal IgA pattern. This case might share common pathological characteristics with the newly described entity referred to as proliferative glomerulonephritis with monoclonal IgG deposits.