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Association of transforming growth factor‐β1 T869C gene polymorphism with diabetic nephropathy risk
Author(s) -
Zhou TianBiao,
Jiang ZongPei,
Qin YuanHan,
Drummen Gregor PC
Publication year - 2014
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12176
Subject(s) - odds ratio , genotype , medicine , diabetic nephropathy , allele , confidence interval , population , gene polymorphism , gastroenterology , genetics , gene , biology , kidney , environmental health
Aim A possible association between the transforming growth factor‐β1 ( TGF ‐β1) T869C gene polymorphism and the risk of developing diabetic nephropathy ( DN ) remains unclear. This investigation was performed to assess if an association between the TGF ‐β1 T869C gene polymorphism and DN risk exists by using meta‐analysis to combine comparable studies, thereby increasing sample size and statistical significance, and to identify patterns in various studies. Methods The association reports were identified from PubMed , C ochrane L ibrary, and CBM ‐disc ( C hina B iological M edicine D atabase) on 1 M ay 2013, and eligible studies were recruited and synthesized. Results Fifty reports were recruited into this meta‐analysis for the association of the TGF ‐β1 T869C gene polymorphism with DN risk. The TT genotype in the overall population was shown to be associated with DN risk (odds ratio ( OR) = 0.74, 95% confidence interval ( CI) : 0.56–0.98, P = 0.04). In the sub‐group analysis, CC genotype was associated with DN risk in Asians, Caucasians, and Africans. However, the sample size for C aucasians and A fricans was relatively small. Furthermore, T allele was distinctly associated with the risk of developing DN in the Asian population ( OR = 0.76, 95% CI : 0.62–0.92, P = 0.005). Conclusions The TT genotype of TGF ‐β1 T869C in the overall population was associated with DN risk, whereas the CC genotype and T allele were distinctly associated with DN risk in the Asian population. Nonetheless, additional studies are required to firmly establish a correlation between the aforementioned polymorphism and DN risk.