Premium
Fetuin‐ A ‐containing calciprotein particle levels can be reduced by dialysis, sodium thiosulphate and plasma exchange. Potential therapeutic implications for calciphylaxis?
Author(s) -
Cai Michael MX,
Smith Edward R,
Brumby Catherine,
McMahon Lawrence P,
Holt Stephen G
Publication year - 2013
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12137
Subject(s) - calciphylaxis , medicine , dialysis , urology , hemodialysis , nephrology , endocrinology , calcification , gastroenterology
Abstract Calciprotein particles ( CPP ) are a novel marker of mineral stress. High levels of CPP are found in patients with calciphylaxis, a condition associated with marked vascular calcification and a poor prognosis. We report substantial reductions in CPP levels in a dialysis patient having combined haemodialysis ( HD ) and plasma exchange ( PEx ) prior to an ABO ‐incompatible kidney transplant. We also report the effects of the same treatments combined with sodium thiosulphate ( STS ) in a patient newly diagnosed with calciphylaxis. Combining HD with intra‐dialytic STS and PEx we achieved a significant reduction in CCP with the least rebound between treatment sessions. After 6 weeks of treatment, the CPP reduction was paralleled by clinical improvement. Measurement of CPP may be an attractive marker for monitoring the effectiveness of calciphylaxis therapy.