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Progenitor programming in mammalian nephrogenesis
Author(s) -
O'Brien Lori L,
McMahon Andrew P
Publication year - 2013
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12027
Subject(s) - progenitor cell , progenitor , nephron , medicine , intervention (counseling) , neuroscience , computational biology , kidney , stem cell , biology , microbiology and biotechnology , psychiatry
Nephrogenesis is dependent on the input of several transcriptional regulatory networks. However, the details of how these networks operate and converge to facilitate nephron progenitor specific programmes are largely unknown. To this end, recent studies have focused on identifying the precise regulatory mechanisms that modulate progenitor maintenance and induction. Continued focus on this area of research will help identify nephrogenic programmes which could be manipulated for therapeutic intervention of kidney disease.