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Smad7 gene transfer attenuates angiogenesis in peritoneal dialysis rats
Author(s) -
Peng Weisheng,
Dou Xianrui,
Hao Wenke,
Zhou Qiaoling,
Tang Rong,
Nie Jing,
Lan Hui Y,
Yu Xueqing
Publication year - 2013
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12017
Subject(s) - angiogenesis , medicine , basic fibroblast growth factor , vascular endothelial growth factor , growth factor , transforming growth factor , downregulation and upregulation , cd31 , cancer research , platelet derived growth factor receptor , smad , neovascularization , western blot , immunology , endocrinology , biology , receptor , gene , biochemistry , vegf receptors
This is an animal study that demonstrated reduced peritoneal angiogenesis through the blockade of transforming growth factor‐β, through signalling with Smad7. This presents a novel therapeutic approach to decrease ultrafiltration failure and hence increase peritoneal dialysis technique longevity.