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Comparing the Montreal Cognitive Assessment with Mini‐Mental State Examination in Japanese Parkinson's disease patients
Author(s) -
Ohta Kouichi,
Osada Takashi,
Shinohara Yukito,
Suzuki Norihiro,
Takahashi Kazushi,
Seki Morinobu,
Nihei Yoshihiro,
Iwasawa Satoko,
Gotoh Jun,
Yamaguchi Keiji,
Komatsumoto Satoru,
Isozumi Kazuo,
Kobari Masahiro,
Mihara Ban,
Morita Yoko,
Yasutomi Daisuke,
Gotoh Kyoko,
Muramatsu Kazuhiro,
Shirai Toshitaka,
Tomita Yutaka,
Sato Hideki
Publication year - 2014
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.80
Subject(s) - medicine , montreal cognitive assessment , dementia , cognitive impairment , parkinson's disease , mini–mental state examination , cognition , disease , physical therapy , psychiatry
Background and Aim The Montreal Cognitive Assessment (Mo CA ) is the most suitable measure for screening cognitive impairment in Parkinson's disease ( PD ). However, the utility of the Mo CA has not been documented sufficiently, especially in Asian populations. The present multicenter study included a large number of Japanese patients, and compared Mini‐Mental State Examination ( MMSE ) and Mo CA scores in PD patients. Methods We carried out a cross‐sectional study. Idiopathic PD patients ( n = 304; age 70.6 ± 8.3 years (mean ± SD); disease duration 6.6 ± 5.1 years; Hoehn and Yahr stage 2.7 ± 0.7) were registered at 13 participating hospitals, and their clinical/neurological/cognitive features were examined using Japanese versions of the MMSE and Mo CA . Results The MMSE and Mo CA scores were 26.3 ± 3.6 (range 12–30) and 20.9 ± 5.0 (range 5–30), respectively, and showed a strong correlation ( R 2 = 0.74, P < 0.001) with each other. A MMSE score of <26 was observed in 35% of the participants. A Mo CA score of <21 had 89% sensitivity and 83% specificity, comparable with a MMSE score of <26. The two scores were correlated with age ( R 2 = 0.12 and 0.20, respectively; P < 0.0001), but not with Hoehn and Yahr stage or disease duration. Conclusions One‐third of the patients had a MMSE score of <26, a diagnostic criterion of PD with dementia. A Mo CA score of <21 seemed comparable with a MMSE score of <26. The two scores were correlated with age, rather than severity of motor symptoms, suggesting that cognitive decline might be independent of motor decline in PD .