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Paraparetic Guillain‐Barré syndrome: Extending the axonal spectrum
Author(s) -
Nagashima Takahide,
Kokubun Norito,
Shahrizaila Nortina,
Funakoshi Kei,
Hirata Koichi,
Yuki Nobuhiro
Publication year - 2013
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.59
Subject(s) - guillain barre syndrome , medicine , campylobacter jejuni , pathophysiology , nerve conduction , serology , antibody , acute motor axonal neuropathy , diarrhea , immunology , pathology , genetics , bacteria , biology
There are few reports of the paraparetic variant of Guillain‐Barré syndrome, and its pathophysiology is not well understood. We report a patient presenting with acute paraparesis following diarrhea. Serial nerve conduction studies suggested primary axonal injury, and not demyelination, predominantly in the lower limbs compared with the upper limbs. There was serological evidence of recent Campylobacter jejuni infection and strongly positive immunoglobulin G anti‐ GD 1a antibodies. Paraparetic Guillain‐Barré syndrome is likely to represent a regional form of Guillain‐Barré syndrome, with a nosological position within the axonal subtype.