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Polyneuritis and refractory headache overlap with synovitis, acne, pustulosis, hyperostosis and osteitis syndrome
Author(s) -
Matsuzono Kosuke,
Hishikawa Nozomi,
Ohta Yasuyuki,
Yamashita Toru,
Deguchi Kentaro,
Abe Koji
Publication year - 2015
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.171
Subject(s) - medicine , pustulosis , hyperostosis , sapho syndrome , osteitis , dermatology , palmoplantar pustulosis , chronic recurrent multifocal osteomyelitis , synovitis , prednisolone , bone scintigraphy , surgery , osteomyelitis , arthritis , radiology , psoriasis
Abstract The primary clinical manifestations of synovitis, acne, pustulosis, hyperostosis and osteitis syndrome are skin lesions and osteitis. We describe a 53‐year‐old woman patient suffering from overlapping refractory headache and polyneuritis (cranial nerves I, II and VII ). She complained of headaches, which recurred every month, followed by bilateral anosmia and left vision loss approximately 1 year later. Prednisolone therapy improved her symptoms; however, her refractory headache, pain in the right shoulder and left hip joint, and rash recurred 1 year after prednisolone withdrawal. Also, the patient presented with left sensorineural deafness and extensive acne on her body, and bone scintigraphy and bone biopsy showed synovitis, acne, pustulosis, hyperostosis and osteitis syndrome. After treatment, her symptoms improved without recurrence. Although synovitis, acne, pustulosis, hyperostosis and osteitis syndrome induced by polyneuritis is rare, it should be considered when clinicians encounter patients presenting with headache and polyneuritis of unknown cause.