Premium
The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration
Author(s) -
Taira Yuki,
Omote Yoshio,
Kawahara Yuko,
Nomura Emi,
Sasaki Ryo,
Matsumoto Namiko,
Matsuoka Chika,
Takemoto Mami,
Morihara Ryuta,
Hishikawa Nozomi,
Yamashita Toru,
Abe Koji
Publication year - 2021
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12514
Subject(s) - medicine , chronic inflammatory demyelinating polyneuropathy , prednisolone , polyneuropathy , sural nerve , weakness , peripheral neuropathy , nerve biopsy , methylprednisolone , nerve conduction study , testosterone (patch) , anesthesia , nerve conduction , surgery , antibody , endocrinology , immunology , diabetes mellitus
We report on a 35‐year‐old man who had gender dysphoria following unilateral ovariectomy and then received continuous testosterone injection for nine years, inducing chronic inflammatory demyelinating polyneuropathy (CIDP). He developed recurrent muscle weakness and numbness in the extremities and displayed demyelinating neuropathy, detected by nerve conduction studies and a sural nerve biopsy. Repeated intravenous immunoglobulin (IVIg) therapy and the administration of oral prednisolone improved symptoms and inhibited their recurrence. A relatively high level of serum testosterone as a genetic female might have caused the neurotoxicity of the peripheral nerve, leading to CIDP.