Premium
A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging
Author(s) -
Ohta Yasuyuki,
Shimada Hitoshi,
Ikegami Ken,
Tsunoda Keiichiro,
Hishikawa Nozomi,
Yamashita Toru,
Takemoto Mami,
Omote Yoshio,
Tagai Kenji,
Matsuoka Kiwamu,
Higuchi Makoto,
Abe Koji
Publication year - 2021
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12463
Subject(s) - parkinsonism , amyotrophic lateral sclerosis , progressive supranuclear palsy , medicine , brainstem , midbrain , dementia , substantia nigra , neuroscience , pathology , parkinson's disease , central nervous system , disease , psychology
Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), frequently observed in the Kii peninsula of Japan, is pathologically characterized by widespread tau pathology in the cerebrum and brainstem. Here, we report a case of Kii ALS/PDC predominantly presenting progressive parkinsonism. Tau positron emission tomography (PET) imaging with 18 F‐PM‐PBB3 suggested tau deposition in the substantia nigra of the midbrain and subcortical areas, but not in the cerebral cortex, which was similar to progressive supranuclear palsy (PSP), suggesting that parkinsonism‐predominant type of Kii ALS/PDC may have a similar area of tau deposition to PSP.