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Functional connectivity in migraineurs with photo‐, phono‐, or osmophobia: A static and dynamic resting‐state functional magnetic resonance imaging study
Author(s) -
Imai Noboru,
Moriya Asami,
Kitamura Eiji
Publication year - 2020
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12440
Subject(s) - phonophobia , resting state fmri , photophobia , functional magnetic resonance imaging , medicine , migraine , neuroscience , psychology , radiology , surgery , aura
Background Migraine attacks are associated with photo‐, phono‐, and osmophobia, which may be caused by different pathophysiological mechanisms because they are not present in all migraineurs. Aim Here, we investigated differences in static and dynamic resting‐state functional connectivities between patients with and without photo‐, phono‐, or osmophobia. Methods Sixty‐two women with migraine with/without photo‐, phono‐, or osmophobia underwent 3‐T functional magnetic resonance imaging during the interictal phase. We compared static and dynamic resting‐state functional connectivities using region of interest‐to‐region of interest analysis of 91 cortical, 15 subcortical, and 26 cerebellar areas. Results The static resting‐state functional connectivity analysis showed that patients with photophobia had 18 different significant connectivity pairs, those with phonophobia had 15, and those with osmophobia had significantly higher connectivity between the right cerebellar lobule and brainstem. The dynamic resting‐state functional connectivity analysis showed that patients with photophobia had 16 different significant connectivity pairs, those with phonophobia had eight without main regions, and those with osmophobia had 14. Static and dynamic functional connectivity alterations in patients with phonophobia and osmophobia had no significant overlapping connectivity pairs. Conclusion Our results showed that static and dynamic resting‐state functional connectivities in migraineurs with and without photo‐, phono‐, or osmophobia differed.