Premium
The relationship between cognitive decline and motor dysfunction in Parkinson’s disease: A focused mini‐review on cognitive‐locomotor dual‐task interference
Author(s) -
Mihara Masahito
Publication year - 2020
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12398
Subject(s) - cognition , task (project management) , neuroscience , basal ganglia , parkinson's disease , dual (grammatical number) , medicine , physical medicine and rehabilitation , elementary cognitive task , cognitive decline , brainstem , disease , psychology , cognitive psychology , central nervous system , pathology , art , dementia , literature , management , economics
Abstract Accumulating evidence suggests that motor symptoms other than resting tremors are affected by coexisting cognitive decline in Parkinson's disease (PD). These cognitive and motor interactions are characterized by the extent to which a concurrent cognitive task affects motor task performance in a dual‐task paradigm. Many studies have investigated cognitive‐postural/locomotor dual‐task interference in PD. Consistent with the notion that bipedal locomotor control requires high cortical demand, previous studies observed greater “dual‐task cost” in patients with PD compared with healthy subjects. This suggests that a segregated cortico‐basal ganglia network is involved in cognitive‐motor dual‐tasking and that cortico‐basal ganglia dysfunction would increase dual‐task interference in patients with PD. In addition, cortico‐brainstem networks may also play an important role in cognitive‐locomotor dual‐task interference. Herein, we discuss possible theoretical models and neural underpinnings of dual‐task interference in PD and future clinical applications of the dual‐task paradigm.