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Prevalence and clinical features of dual diseases of Alzheimer's disease and dementia with Lewy bodies: A neuroimaging‐based study
Author(s) -
Sakakibara Ryuji,
Tateno Fuyuki,
Aiba Yosuke,
Ogata Tsuyoshi,
Kishi Masahiko,
Terada Hitoshi,
Inaoka Tsutomu,
Nakatsuka Tomoya,
Katsuragawa Shuichi,
Kato Yuuki
Publication year - 2019
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12297
Subject(s) - dementia with lewy bodies , medicine , dementia , prospective cohort study , disease , lewy body , neuroimaging , cohort , parkinson's disease , pediatrics , movement disorders , psychiatry
Background While dual diseases of Alzheimer's disease ( AD ) and dementia with Lewy bodies ( DLB ) are documented pathologically, few studies are available concerning the frequency of dual diseases. Aim We present our data of the frequency of AD , DLB and dual diseases based on neuroimaging, together with the frequency of Parkinson's disease ( PD ) without dementia. Methods This is a prospective cohort study (745 dementia and/or movement disorder referred patients; recruiting period, 3 years; prospectively follow‐up period, 2.0 ± 1.8 years; age 73.0 ± 6.3 years at the first visit; 360 men, 385 women; all underwent MRI scan). Patients met the published criteria at least once during a course of disease. We included both dopaminergic denervation in the striatum and noradrenergic denervation in the heart to the inclusion criteria of DLB and PD . Results Among them, total 476 patients met the criteria as follows: 232 AD (48.7%), 91 DLB (19.1%), 29 dual diseases (6.1%), and 124 PD (26.1%). Patients with dual diseases were initially diagnosed as AD in 18, PD in 8, DLB in two, and Lewy body disease in one. Conclusion In the cases presented, 6.1% of patients who visited dementia/movement disorder clinics showed duals diseases. It is therefore important to follow such patients, from the view point of disease progression and necessary care.