Premium
Proteinuria in neuronal intranuclear inclusion disease
Author(s) -
Fukai Yuta,
Yorimitsu Daisuke,
Nishimura Hirotake,
Kutoku Yumiko,
Sasaki Tamaki,
Kashihara Naoki,
Ohsawa Yutaka,
Sunada Yoshihide
Publication year - 2018
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12182
Subject(s) - medicine , proteinuria , pathology , eosinophilic , ataxia , magnetic resonance imaging , biopsy , renal biopsy , radiology , kidney , psychiatry
Recently, clinical features of adult‐onset neuronal intranuclear inclusion disease have gradually become characterized by premortem diagnoses based on eosinophilic, ubiquitin‐positive intranuclear inclusions demonstrated using skin biopsy specimens. A 65‐year‐old healthy woman with proteinuria was admitted because of cognitive impairment and walking instability. She had frontal lobe dysfunction and sensory ataxia with high‐signal‐intensity lesions in the corticomedullary junction on performing diffusion‐weighted brain magnetic resonance imaging. She was incidentally diagnosed with adult‐onset sporadic neuronal intranuclear inclusion disease based on the presence of intranuclear inclusions in renal biopsy specimens. Proteinuria might be a non‐neuronal symptom of neuronal intranuclear inclusion disease because no other causes for proteinuria were found on renal testing.