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Japanese sibling cases of multiple sclerosis presenting with different clinical phenotypes
Author(s) -
Sato Kota,
Ohta Yasuyuki,
Yamashita Toru,
Tsunoda Keiichiro,
Deguchi Kentaro,
Takemoto Mami,
Hishikawa Nozomi,
Abe Koji
Publication year - 2017
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12145
Subject(s) - multiple sclerosis , medicine , sibling , phenotype , clinical phenotype , pediatrics , immunology , genetics , gene , developmental psychology , psychology , biology
Unlike in Western countries, only a few familial multiple sclerosis cases have been reported from Asian countries. Herein, we report on the characteristics of siblings with multiple sclerosis. Their parents were consanguineous, and the siblings showed different first symptoms of gait disturbance or double vision, with a clinical phenotype of primary progressive multiple sclerosis or relapse–remitting multiple sclerosis. Their human leukocyte antigen showed unique subtypes of DPB 1 (0501/0901 or 0901/0901) and DRB 1 (0406/1502 or 1502/1502).