Premium
Case of myasthenia gravis and Lambert–Eaton myasthenic syndrome overlap syndrome accompanied by autoimmune encephalitis and cerebellar ataxia with multiple neuronal antibodies
Author(s) -
Nakano Yumiko,
Nomura Emi,
Yamashita Toru,
Sato Kota,
Takemoto Mami,
Hishikawa Nozomi,
Ohta Yasuyuki,
Abe Koji
Publication year - 2017
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12134
Subject(s) - lambert eaton myasthenic syndrome , medicine , myasthenia gravis , cerebellar ataxia , autoimmune encephalitis , glutamate decarboxylase , acetylcholine receptor , ataxia , immunology , antibody , overlap syndrome , autoantibody , pathology , receptor , disease , psychiatry , biochemistry , chemistry , enzyme
A 72‐year‐old woman developed a subacute series of encephalitis, cerebellar ataxia, and combined symptoms of both myasthenia gravis and Lambert–Eaton myasthenic syndrome. Seven different neuronal antibodies were detected for Hu, glutamic acid decarboxylase, acetylcholine receptor, P/Q‐type voltage‐gated calcium‐channels, Zic4, Titin and SOX 1 in her serum with intrathecal synthesis of glutamic acid decarboxylase antibodies. Although she showed classical manifestations with onconeural antibodies, she was diagnosed with not paraneoplastic but autoimmune neurological syndrome because of no underlying tumor and good response to immunotherapies. The present case is very unique and rare for complex neurological disorders including myasthenia gravis and Lambert–Eaton myasthenic syndrome overlap syndrome with multiple neuronal antibodies.