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Internal carotid artery occlusion and cerebral infarction in a case of juvenile systemic lupus erythematosus and positive for phosphatidylserine dependent antiprothrombin antibody
Author(s) -
Naoi Tameto,
Kameda Tomoaki,
Oku Kenji,
Ando Ayako,
Hayashi Yuka,
Miyamoto Michiaki,
Suzuki Hiromi,
Kawakami Tadataka
Publication year - 2017
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12112
Subject(s) - medicine , phosphatidylserine , cerebral infarction , occlusion , thrombosis , cardiology , infarction , cerebral vasculitis , vasculitis , antiphospholipid syndrome , ischemia , myocardial infarction , phospholipid , genetics , disease , membrane , biology
Antiphospholipid antibodies are a major risk factor of juvenile cerebral infarction; in addition, they can cause major arterial stenosis or occlusion. We report a case of a 32‐year‐old man who had been diagnosed with systemic lupus erythematosus at the age of 20 years, and was admitted to Shin‐Oyama City Hospital, Tochigi, Japan, because of left arm weakness. Cerebral infarction and occlusion of the right internal carotid artery were found. Tests were positive for phosphatidylserine‐dependent antiprothrombin antibody, which can be useful for the diagnosis of antiphospholipid syndrome. Phosphatidylserine‐dependent antiprothrombin antibody might have the potential to cause thrombosis and vasculitis‐like occlusion.