Subacute lobar encephalitis presenting as cerebellar ataxia and generalized cognitive impairment with positive anti‐glutamate receptor antibodies | Zendy

Nagasako Yuki | Zendy; Sakurai Yasuhisa | Zendy; Sugimoto Izumi | Zendy; Takahashi Yukitoshi | Zendy

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Subacute lobar encephalitis presenting as cerebellar ataxia and generalized cognitive impairment with positive anti‐glutamate receptor antibodies

Author(s) -

Nagasako Yuki,

Sakurai Yasuhisa,

Sugimoto Izumi,

Takahashi Yukitoshi

Publication year - 2016

Publication title -

neurology and clinical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

0

ISSN - 2049-4173

DOI - 10.1111/ncn3.12084

Subject(s) - medicine , glutamate receptor , ataxia , encephalitis , cerebellar ataxia , antibody , immunology , cerebellum , receptor , psychiatry , virus

We report a patient with anti‐glutamate receptor (GluN2B, GluN1 and GluD2) antibody‐positive and anti‐N‐methyl‐ d ‐aspartate receptor antibody‐negative encephalitis presenting as cerebellar ataxia and generalized cognitive impairment. Intravenous corticosteroid pulse therapy markedly resolved his symptoms 6 weeks after onset. Marked impairment of the cortical function with a relatively preserved level of consciousness, and a favorable response to corticosteroid therapy might occur in immune‐mediated lobar encephalitis associated with anti‐glutamate receptor antibodies.

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