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Subacute lobar encephalitis presenting as cerebellar ataxia and generalized cognitive impairment with positive anti‐glutamate receptor antibodies
Author(s) -
Nagasako Yuki,
Sakurai Yasuhisa,
Sugimoto Izumi,
Takahashi Yukitoshi
Publication year - 2016
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12084
Subject(s) - medicine , glutamate receptor , ataxia , encephalitis , cerebellar ataxia , antibody , immunology , cerebellum , receptor , psychiatry , virus
We report a patient with anti‐glutamate receptor (GluN2B, GluN1 and GluD2) antibody‐positive and anti‐N‐methyl‐ d ‐aspartate receptor antibody‐negative encephalitis presenting as cerebellar ataxia and generalized cognitive impairment. Intravenous corticosteroid pulse therapy markedly resolved his symptoms 6 weeks after onset. Marked impairment of the cortical function with a relatively preserved level of consciousness, and a favorable response to corticosteroid therapy might occur in immune‐mediated lobar encephalitis associated with anti‐glutamate receptor antibodies.