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Quantitative reference value of dopamine transporter single‐photon emission computed tomography in healthy Japanese older adults
Author(s) -
Koh Jinsoo,
Yamamoto Kazumi,
Sakata Mayumi,
Murata Kenya,
Ito Hidefumi
Publication year - 2016
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12082
Subject(s) - medicine , dopamine transporter , parkinsonism , single photon emission computed tomography , nuclear medicine , confidence interval , attenuation , emission computed tomography , dopamine , dopaminergic , positron emission tomography , optics , disease , physics
Background N‐ω‐fluoropropyl‐2b‐carbomethoxy‐3b‐(4‐ 123 I‐iodophenyl) nortropane ( 123 I‐ FP ‐ CIT ) single‐photon emission computed tomography is an effective diagnostic tool for parkinsonism . However, a lack of quantitative reference values of the specific binding ratio of normal Japanese controls is a crucial limitation when we apply this procedure for evaluating Japanese parkinsonian patients. Aim In the present study, we aimed to obtain a control database of specific binding ratio in healthy, Japanese older adults. Methods We studied 123 I‐ FP ‐ CIT single‐photon emission computed tomography in 20 healthy Japanese older adults, and obtained the specific binding ratio with and without attenuation correction. Results Clinically and practically relevant data were obtained from 19 participants (10 women, 9 men, age 68.7 ± 8.8 years). The mean specific binding ratio with attenuation correction ± standard deviation was 6.84 ± 1.01, being significantly higher than that of the preceding study of Caucasians by Tossici‐Bolt et al . The mean specific binding ratio without attenuation correction was 5.31 ± 1.04. These were not different between the sexes. The specific binding ratio decreased age‐dependently in the specific binding ratio both with and without attenuation correction. The mean decreasing rate of specific binding ratio with AC was approximately 0.7 per decade. Most of the striatal asymmetry index of specific binding ratio with AC was lower than 8.4%. Conclusion We presented the quantitative reference values of Japanese healthy older adults feasible for diagnostic and research use for Japanese parkinsonian patients.