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Miller Fisher syndrome associated with polymyoclonus
Author(s) -
Inoue Manabu,
Yamamoto Masayoshi,
Tsuzaki Koji,
Murakata Kenji,
Hamano Toshiaki,
Shibasaki Hiroshi
Publication year - 2016
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12030
Subject(s) - medicine , myoclonus , electromyography , dysarthria , reflex , neurological examination , anesthesia , physical medicine and rehabilitation , surgery , audiology
We described a 35‐year‐old man who presented with diplopia, dysarthria, loss of deep tendon reflexes, and rapidly progressive unsteadiness in standing and walking. Two days after admission, frequent, irregular, and shock‐like movements appeared in the hands and abdomen. On laboratory examination, serum immunoglobulin G antibodies against GQ 1b, GT 1a and GD 1b were all positive. Electrophysiologically, recording of the involuntary movements with surface electromyography showed irregular sharp discharges especially during weak muscle contraction. The clinical diagnosis of Miller Fisher syndrome associated with polymyoclonus was made, and all neurological symptoms including myoclonus improved after intravenous injection of immunoglobulin. The distribution of myoclonus and electrophysiological data suggested that the myoclonus, though different from propriospinal or spinal segmental myoclonus in the distribution and propagation, might still be of spinal cord origin.