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Dorsal root enhancement in paraneoplastic sensory ataxic neuropathy with anti‐Hu antibody
Author(s) -
Shibui Aya,
Kobayashi Junpei,
Kuroda Hiroshi,
Aoki Masashi
Publication year - 2016
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12020
Subject(s) - medicine , spinal cord , wallerian degeneration , sensory system , magnetic resonance imaging , pathology , posterior column , anatomy , neuroscience , radiology , biology , psychiatry , acetabulum
Abstract Magnetic resonance imaging findings of paraneoplastic sensory ataxic neuropathy have previously shown that spinal cord lesions are located in the dorsal column. We report a 65‐year‐old man with paraneoplastic sensory ataxic neuropathy of subacute onset presenting dorsal root enhancement on magnetic resonance imaging. Pathological studies found that, in patients with sensory ataxic neuropathy associated with lung cancer, the dorsal roots and ganglia were severely degenerated with inflammatory cell infiltration, whereas the dorsal columns of the spinal cord were simply degenerated without inflammatory reaction, indicating centripetal Wallerian degeneration. There have been no radiological reports describing the preceding steps of Wallerian degeneration in the dorsal column, indicating the disruption of dorsal root ganglia. In the present case, we showed direct evidence of root inflammation detected as dorsal root enhancement in a patient with paraneoplastic sensory ataxic neuropathy of subacute onset.