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Paraneoplastic neuromyelitis optica spectrum disorder manifesting as intractable nausea and acute cerebellar ataxia associated with lung adenocarcinoma
Author(s) -
Kobata Masako,
Okada Kazumasa,
Hashimoto Tomoyo,
Matsuyama Atsuji,
Uchibori Ayumi,
Takahashi Toshiyuki,
Adachi Hiroaki
Publication year - 2015
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.12006
Subject(s) - neuromyelitis optica , medicine , nausea , adenocarcinoma , ataxia , pathology , vomiting , cerebellar ataxia , lung , aquaporin 4 , adenocarcinoma of the lung , gastroenterology , antibody , immunology , cancer , psychiatry
We report a 65‐year‐old woman with neuromyelitis optica spectrum disorder manifesting acute cerebellar ataxia, and intractable nausea and vomiting. She tested positive for anti‐aquaporin 4 antibodies and had a lung adenocarcinoma simultaneously. She underwent partial pulmonary resection, and tumor cells of the lung adenocarcinoma were stained with an anti‐aquaporin 4 antibody. By administering intravenous methyl prednisolone and plasma exchange, aquaporin 4 antibody titer was reduced, and neurological deficits and the lesion status on magnetic resonance imaging markedly improved. Paraneoplastic neuromyelitis optica spectrum disorder in conjunction with lung adenocarcinoma was a reasonable diagnosis.