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Cerebral amyloid angiopathy‐related leukoencephalopathy: Successful steroid treatment for neurological deficits and subcortical white matter lesions partly involving the cortical gray matter
Author(s) -
Murakami Takenobu,
Morimoto Julia,
Hoshi Akihiko,
NakataniEnomoto Setsu,
Ichikawa Masahiro,
Tasaki Kazuhiro,
Ogura Ryosuke,
Toyoshima Yasuko,
Kakita Akiyoshi,
Saito Kiyoshi,
Takahashi Hitoshi,
Ugawa Yoshikazu
Publication year - 2014
Publication title -
neurology and clinical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2049-4173
DOI - 10.1111/ncn3.101
Subject(s) - cerebral amyloid angiopathy , medicine , white matter , pathology , magnetic resonance imaging , leukoencephalopathy , hyperintensity , pathological , amyloid (mycology) , hemiparesis , dementia , radiology , disease , lesion
A 76‐year‐old woman developed subacute cognitive decline, consciousness impairment and right hemiparesis. Magnetic resonance imaging showed asymmetric white matter or cortical gray matter lesions, and multiple cerebral microbleeds. Pathological studies of biopsied brain specimen disclosed amyloid β‐protein deposits in the vessel walls. Repeated steroid‐pulse therapy improved clinical symptoms and resolved the cortico‐subcortical lesions. Steroid therapy should be considered for patients with amyloid β‐protein deposition in cerebral amyloid angiopathy‐related leukoencephalopathy.