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Concomitant LATE‐NC in Alzheimer's disease is not associated with increased tau or amyloid‐β pathological burden
Author(s) -
McAleese K. E.,
Walker L.,
Erskine D.,
Johnson M.,
Koss D.,
Thomas A. J.,
Attems J.
Publication year - 2020
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12664
Subject(s) - alzheimer's disease , tau protein , amygdala , pathological , medicine , concomitant , hyperphosphorylation , psychology , disease , cognitive decline , amyloid (mycology) , pathology , endocrinology , neuroscience , dementia , biology , biochemistry , kinase
The presence of Limbic‐predominant age‐related TDP‐43 encephalopathy neuropathological change (LATE‐NC) is not associated with an increase in the burden of early or late tau or Aβ pathology in Alzheimer's disease. LATE‐NC is associated with a lower final MMSE score independent of tau pathology.