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Signs of early cellular dysfunction in multiple system atrophy
Author(s) -
HerreraVaquero M.,
HerasGarvin A.,
Krismer F.,
Deleanu R.,
Boesch S.,
Wenning G. K.,
Stefanova N.
Publication year - 2021
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12661
Subject(s) - oxidative stress , biology , microbiology and biotechnology , mitochondrion , immunocytochemistry , atrophy , intracellular , induced pluripotent stem cell , pathology , endocrinology , medicine , biochemistry , genetics , embryonic stem cell , gene
Neural progenitors derived from iPSCs of patients with multiple system atrophy show changes in the mitochondrial morphology, relocation of α‐synuclein to the nucleus, and increased susceptibility to exogenous oxidative stress. The findings suggest early cellular dysfunction preceding α‐synuclein aggregate formation in this disorder.