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Hippocampal subfield pathologic burden in Lewy body diseases vs . Alzheimer’s disease
Author(s) -
Coughlin D. G.,
Ittyerah R.,
Peterson C.,
Phillips J. S.,
Miller S.,
Rascovsky K.,
Weintraub D.,
Siderowf A. D.,
Duda J. E.,
Hurtig H. I.,
Wolk D. A.,
McMillan C. T.,
Yushkevich P. A.,
Grossman M.,
Lee E. B.,
Trojanowski J. Q.,
Irwin D. J.
Publication year - 2020
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12659
Subject(s) - subiculum , hippocampal formation , entorhinal cortex , lewy body , pathology , hippocampus , alzheimer's disease , dementia , episodic memory , medicine , pathological , neuroscience , psychology , disease , dentate gyrus , cognition
Lewy body diseases (LBD) are characterized by alpha‐synuclein (SYN) pathology, but co‐morbid Alzheimer’s disease pathology is common and the relationship between these pathologies in microanatomic hippocampal subfields is understudied. Here, we use digital histological methods to measure the distribution, severity, and association of alpha‐SYN, tau, and amyloid‐β pathology in hippocampla subfields in LBD and Alzheimer's disease subjects. We also correlate pathologic burden with antemortem episodic memory testing.