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The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second‐generation subtypes
Author(s) -
Hicks D.,
Rafiee G.,
Schwalbe E. C.,
Howell C. I.,
Lindsey J. C.,
Hill R. M.,
Smith A. J.,
Adidharma P.,
Steel C.,
Richardson S.,
Pease L.,
Danilenko M.,
Crosier S.,
Joshi A.,
Wharton S. B.,
Jacques T. S.,
Pizer B.,
Michalski A.,
Williamson D.,
Bailey S.,
Clifford S. C.
Publication year - 2021
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12656
Subject(s) - medulloblastoma , medicine , oncology , biomarker , subtyping , bioinformatics , pathology , biology , genetics , computer science , programming language
We characterize the subgroup‐dependent clinico‐molecular landscape of infant medulloblastoma, and also consider the importance of recently‐described subtypes of subgroups. We develop and validate subgroup‐specific survival models and proffer suggestions for the incorporation of subgroup/subtype information into future clinical decision making.