Extracellular matrix remodelling is associated with muscle force increase in overloaded mouse  plantaris  muscle | Zendy

Stantzou A. | Zendy; Relizani K. | Zendy; MoralesGonzalez S. | Zendy; Gallen C. | Zendy; Grassin A. | Zendy; Ferry A. | Zendy; Schuelke M. | Zendy; Amthor H. | Zendy

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Extracellular matrix remodelling is associated with muscle force increase in overloaded mouse plantaris muscle

Author(s) -

Stantzou A.,

Relizani K.,

MoralesGonzalez S.,

Gallen C.,

Grassin A.,

Ferry A.,

Schuelke M.,

Amthor H.

Publication year - 2021

Publication title -

neuropathology and applied neurobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.538

H-Index - 95

eISSN - 1365-2990

pISSN - 0305-1846

DOI - 10.1111/nan.12655

Subject(s) - myostatin , muscle hypertrophy , extracellular matrix , itga7 , skeletal muscle , muscular dystrophy , plantaris muscle , myocyte , endocrinology , downregulation and upregulation , medicine , microbiology and biotechnology , duchenne muscular dystrophy , muscle tissue , biology , collagen vi , chemistry , soleus muscle , biochemistry , gene

Overload induced muscle dystrophy causes extracellular matrix remodelling as seen by upregulation of genes associated with the gene ontology (GO)‐terms “collagen metabolism”, “metalloproteinases”, and “inflammatory response”. These changes go in parallel with a more than twofold increase in muscle force and muscle weight.

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