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Extracellular matrix remodelling is associated with muscle force increase in overloaded mouse plantaris muscle
Author(s) -
Stantzou A.,
Relizani K.,
MoralesGonzalez S.,
Gallen C.,
Grassin A.,
Ferry A.,
Schuelke M.,
Amthor H.
Publication year - 2021
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12655
Subject(s) - myostatin , extracellular matrix , muscle hypertrophy , itga7 , muscular dystrophy , skeletal muscle , plantaris muscle , myocyte , endocrinology , downregulation and upregulation , medicine , duchenne muscular dystrophy , muscle tissue , collagen vi , biology , microbiology and biotechnology , myosin , chemistry , soleus muscle , biochemistry , gene
Overload induced muscle dystrophy causes extracellular matrix remodelling as seen by upregulation of genes associated with the gene ontology (GO)‐terms “collagen metabolism”, “metalloproteinases”, and “inflammatory response”. These changes go in parallel with a more than twofold increase in muscle force and muscle weight.