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Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours
Author(s) -
Prabowo Avanita S.,
Thuijl Hinke Foka,
Scheinin Ilari,
Sie Daoud,
Essen Hendrik F.,
Iyer Anand M.,
Spliet Wim G.M.,
Ferrier Cyrille H.,
Rijen Peter C.,
Veersema Tim J.,
Thom Maria,
Schoutenvan Meeteren Annetteke Y.N.,
Reijneveld Jaap C.,
Ylstra Bauke,
Wesseling Pieter,
Aronica Eleonora
Publication year - 2015
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12235
Subject(s) - pathology , chromosome , astrocytoma , comparative genomic hybridization , copy number variation , biology , chromothripsis , glioma , immunohistochemistry , medicine , genome , cancer research , genetics , gene , dna , genome instability , dna damage
Aim Gangliogliomas ( GG s) and dysembryoplastic neuroepithelial tumours ( DNT s) represent the most common histological entities within the spectrum of glioneuronal tumours ( GNT s). The wide variability of morphological features complicates histological classification, including discrimination from prognostically distinct diffuse low‐grade astrocytomas ( AII s). This study was performed to increase our understanding of these tumours. Methods We studied chromosomal copy number aberrations ( CNAs ) by genome‐wide sequencing in a large cohort of GNT s and linked these to comprehensive histological analysis and clinical characteristics. One hundred fourteen GNT s were studied: 50 GG s and 64 DNT s. Also, a data set of CNAs from 38 diffuse AII s was included. Results The most frequent CNAs in both GG s and DNT s were gains at chromosomes 5 and 7, often concurrent, and gain at chromosome 6. None of the CNAs was linked to histological subtype, immunohistochemical features or to clinical characteristics. Comparison of AII s and diffuse GNT s revealed that gain at whole chromosome 5 is only observed in GNT s. CNA patterns indicative of chromothripsis were detected in three GNT s. Conclusion We conclude that GNTs with diverse morphologies share molecular features, and our findings support the need to improve classification and differential diagnosis of tumour entities within the spectrum of GNT s, as well as their distinction from other gliomas.