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Invited review: Frontotemporal dementia caused by microtubule‐associated protein tau gene ( MAPT ) mutations: a chameleon for neuropathology and neuroimaging
Author(s) -
Ghetti Bernardino,
Oblak Adrian L.,
Boeve Bradley F.,
Johnson Keith A.,
Dickerson Bradford C.,
Goedert Michel
Publication year - 2015
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12213
Subject(s) - frontotemporal dementia , neuropathology , tau protein , dementia , neuroimaging , magnetic resonance imaging , pathology , asymptomatic , neuroscience , biology , medicine , alzheimer's disease , disease , radiology
Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene ( MAPT ) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.