Premium
Angiocentric glioma: a report of nine new cases, including four with atypical histological features
Author(s) -
Ni HaiChun,
Chen ShiYun,
Chen Li,
Lu DeHong,
Fu YongJuan,
Piao YueShan
Publication year - 2015
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12158
Subject(s) - pathology , vimentin , glial fibrillary acidic protein , glioma , ganglioglioma , biology , staining , histopathology , epilepsy , isocitrate dehydrogenase , central nervous system , immunohistochemistry , medicine , biochemistry , cancer research , neuroscience , enzyme
Aims Angiocentric glioma ( AG ) is a rare, slow‐growing tumour of the central nervous system. It is often associated with refractory epilepsy and occurs most commonly in children and young adults. We herein report nine cases of AG , including four with atypical histological findings. Methods The clinical data and clinicopathological findings of nine cases with AG histological features were described. Results All nine patients had a history of refractory epilepsy with a mean history of 4.4 years and a median age of 17.6 years at surgery. The AG lesions were located in the superficial cerebrocortical region. Histological examination of these cases revealed characteristic structural features of AG , including bipolar spindle‐shaped cells with an angiocentric growth pattern. However, four cases also exhibited atypical histological features: one had astroblastoma‐like characteristics, two had a distinct cystic region with an onion‐like structure and myxoid changes, and the other one had a region involving many abnormal neurones reminiscent to ganglioglioma. All were positive for glial fibrillary acidic protein and vimentin. Eight cases were positive for epithelial membrane antigen ( EMA ), with a dot‐like staining pattern. A diffuse D 2‐40 staining was visible in these cases, with two having similar staining pattern to EMA . All cases were immunonegative for BRAF V 600 E and isocitrate dehydrogenase‐1 R 132 H mutations. Conclusions Our results demonstrate that atypical histological features can be present in AG . A collection of more cases and further molecular analyses are required to confirm our findings.