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Review: Microglia in protein aggregation disorders: friend or foe?
Author(s) -
Gentleman S. M.
Publication year - 2013
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/nan.12017
Subject(s) - microglia , pathogenesis , disease , pathological , neuroscience , protein aggregation , medicine , immunology , biology , pathology , inflammation , microbiology and biotechnology
Microglia cells have been implicated, to some extent, in the pathogenesis of all of the common neurodegenerative disorders involving protein aggregation such as A lzheimer's disease, P arkinson's disease and A myotrophic L ateral S clerosis. However, the precise role they play in the development of the pathologies remains unclear and it seems that they contribute to the pathological process in different ways depending on the specific disorder. A better understanding of their varied roles is essential if they are to be the target for novel therapeutic strategies.