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Zur Wachstumshemmung pathogener Hefen durch Pseudomonas aeruginosa in vitro : Ihre klinische Bedeutung in Blutkulturen
Author(s) -
Grillot R.,
Portmann-Coffin V.,
Ambroise-Thomas P.
Publication year - 1994
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.1994.37.9-10.343
Subject(s) - microbiology and biotechnology , pseudomonas aeruginosa , biology , cryptococcus neoformans , yeast , candida parapsilosis , candida tropicalis , candida albicans , in vitro , candida glabrata , colony forming unit , bacteria , corpus albicans , biochemistry , genetics
Summary The interaction between yeasts and bacteria may have clinical implications in polymicrobial septicaemia. The in vitro effect of Pseudomonas aeruginosa on five pathogenic yeast species, Candida albicans, Candida tropicalis, Candida parapsilosis, Candida glabrata and Cyptococcus neoformans, was investigated. Yeast inhibition assays were performed in an aerobic blood culture medium, inoculated with yeast cells (inoculum 1–10 CFU ml −1 ) and bacterial cells (inoculum 10−10 7 CFU m1 −1 ). Interactions between P. aeruginosa and yeasts were determined after incubation by enumeration of pure and mixed cultures. Growth of all isolates tested was completely or partially inhibited by P. aeruginosa in blood culture medium, the phenomenon depending on the yeast genus and bacterial inoculum. Suppression of fungal growth was also observed in bacterial culture filtrate. This in vitro antifungal activity may preclude yeast recovery from blood cultures in mixed infections.