Die Wirkung von Amorolfin und Oxiconazol auf die Ultrastruktur von Trichophyton mentagrophytes im Vergleich

Summary Amorolfine applied in concentrations of 0.1–100 μ g ml −1 caused considerable damages to the ultrastructure of Trichophyton mentagrophytes : Electron‐transparent areas appear in the cytoplasma. The cell wall increases in thickness. Extracytoplasmic membrane vesicles are formed and deposited in the cell wall. Starved fungal cells, with normal ultrastructure, can be found. Lysed, dead cells demonstrate the process of final, vigorous ultrastructural damage. The feature of the damage caused by amorolfine is comparable to that effected by azole antifungals. The characteristics of the ultrastructural changes are similar to those due to amorolfine in the yeast species Candida albicans .