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Experimentelle Dermatophytose bei Nacktmeerschweinchen im Vergleich zur Infektion bei Pirbright‐White‐Tieren
Author(s) -
Hänel H.,
Braun Bettina,
Löschhorn Karin
Publication year - 1990
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.1990.33.4.179
Subject(s) - hairless , trichophyton , strain (injury) , guinea pig , medicine , dermatology , biology , white (mutation) , veterinary medicine , antifungal , genetics , biochemistry , gene
Summary With this investigation we wanted to compare the suitability oftwo different strains of guinea pigs to evaluate topical antifungals after experimental Trichophyton mentagrophytes infection. The “hairless”‐strain was compared with the hairy Pirbright White strain. The infection areas were treated with a skin retention test (application before infection) and two sets of therapy tests (application after infection). In the retention test the different antimycotic compounds led to better gradations. Also, in the two sets of therapy tests the gradations among the compounds were more clearly and more comparable to published results of clinical trials. In the histological investigations the infections in the "hairless" animals developed in a way which is known from dermatophytoses in human skin. In the Pirbright White strain, however, due to the adjacent hair roots, a marked inflammatory reaction of the tissue persisted for 3 weeks which is not observed on human skin of the trunk and extremities. We, therefore, consider the "hairless" strain of guinea pigs to be more suitable than hairy animals for the comparison of topical antimycotics.