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Clotrimazol und Bifonazol in der Lokalbehandlung der Candida ‐Keratitis beim Kaninchen
Author(s) -
Behrens-Baumann W.,
Klinge B.,
Uter W.
Publication year - 1990
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.1990.33.11-12.567
Subject(s) - bifonazole , clotrimazole , cornea , medicine , corneal epithelium , debridement (dental) , candida albicans , ophthalmology , keratitis , fungal keratitis , surgery , antifungal , dermatology , biology , microbiology and biotechnology
Summary Using a reproducible model of Candida albicans keratitis in rabbits we studied the effect of topical clotrimazole and bifonazole. Candida albicans DSM 70010 (2.5 × 10 5 cells) was injected into the corneal stroma of both eyes of 28 rabbits. All eyes developed a corneal ulcer. Fourtye‐ight hours after inoculation the animals were divided into four groups: I (14 eyes) receiving 10 × clotrimazole 1% drops and subsequently removing the epithelium; II (14 eyes) receiving only clotrimazole drops; III (8 eyes) receiving 6 × bifonazole 1% drops and IV (19 eyes) serving as control (0.9% NaCI, castor oil, untreated), 6 eyes of this group were also debrided. A further 6 rabbits were used respectively to judge if the drugs penetrated into the cornea and aqueous humor. There was a significant difference between the clotrimazole group with debridement (I) and the bifonazole group (III) compared with the control group (IV) concerning hypopyon and complications (descemetocele, corneal perforation). Clotrimazole penetrated into the cornea and after debridement into the aqueous humor. Bifonazole could not be identified in the cornea or aqueous humor.