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Alternative treatment of fungal infections: Synergy with non‐antifungal agents
Author(s) -
Rossato Luana,
Camargo dos Santos Marielle,
Vitale Roxana G.,
Hoog Sybren,
Ishida Kelly
Publication year - 2021
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.13203
Subject(s) - antifungal , antifungal drugs , antifungal drug , intensive care medicine , echinocandins , drug , drug resistance , medicine , pharmacology , biology , caspofungin , amphotericin b , microbiology and biotechnology , dermatology
Abstract Fungal infections are responsible for high mortality rates in immunocompromised and high‐risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies for novel and effective antifungal drugs. Synergistic combinations of antifungals with non‐antifungal agents highlight a pragmatic strategy to reduce the development of drug resistance and potentially repurpose known compounds with other functions to bypass costly and time‐consuming novel drug development.