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Pregnancy complicated by allergic bronchopulmonary aspergillosis: A case‐control study
Author(s) -
Sehgal Inderpaul Singh,
Dhooria Sahajal,
Thurai Prasad Kuruswamy,
Muthu Valliappan,
Aggarwal Ashutosh Nath,
Chakrabarti Arunaloke,
Agarwal Ritesh
Publication year - 2021
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.13180
Subject(s) - medicine , allergic bronchopulmonary aspergillosis , pregnancy , bronchiectasis , asthma , pediatrics , obstetrics , pulmonary function testing , immunology , immunoglobulin e , lung , biology , antibody , genetics
Summary Background Whether allergic bronchopulmonary aspergillosis (ABPA) affects maternal and perinatal outcomes during pregnancy or vice versa is unknown. Objective To evaluate the course of ABPA and its consequence on maternal and perinatal outcomes during pregnancy. Methods We retrospectively included pregnant women with ABPA (cases) and compared them with non‐pregnant ABPA subjects (controls). We recorded the following details in cases and controls: demographical characteristics, radiological findings, pulmonary function, duration of symptoms and the number of asthma and ABPA exacerbations during follow‐up. We also recorded the maternal and perinatal outcomes in the cases. Results We included nine cases and 38 controls with a similar age range. All the cases had achieved remission of ABPA before pregnancy and were receiving inhaled medications for asthma control. Serum total IgE levels, the extent of bronchiectasis on CT thorax and pulmonary function were comparable in the two groups. The mean number of asthma (53 vs 7) and ABPA (62 vs 16) exacerbations per 100 person‐years was significantly higher in cases compared to the controls. We did not observe any maternal complications. One neonate had low birthweight. Conclusions The risk of asthma and ABPA exacerbations is significantly higher in pregnant subjects with ABPA than non‐pregnant women with ABPA. However, maternal and perinatal outcomes are good.