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Investigation of a healthcare‐associated Candida tropicalis candidiasis cluster in a haematology unit and a systematic review of nosocomial outbreaks
Author(s) -
Barac Aleksandra,
Cevik Muge,
Colovic Natasa,
Lekovic Danijela,
Stevanovic Goran,
Micic Jelena,
Rubino Salvatore
Publication year - 2020
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.13048
Subject(s) - candida tropicalis , outbreak , medicine , infection control , neutropenia , intensive care unit , cluster (spacecraft) , health care , antibiotics , intensive care medicine , pediatrics , antifungal , microbiology and biotechnology , dermatology , pathology , biology , toxicity , computer science , programming language , economics , economic growth
Summary Background Non‐albicans Candida spp. are an emerging cause of hospital‐acquired bloodstream infections, associated with high mortality due to the challenges in diagnosis and delayed treatment. Objectives We aimed to investigate a cluster of healthcare‐associated invasive candidiasis caused by C tropicalis and review the literature of healthcare‐associated outbreaks or clusters caused by C tropicalis . Methods An investigation was performed to determine clinical presentation, treatment outcomes and the factors contributing to C tropicalis candidemia occurrence. We searched the Medline database via PubMed and Ovid using the keywords of “Candida tropicalis” combined with “outbreak” or “clustering” or “clusters,” and we limited the search to studies conducted from January 1989 to January 2019. Results We report two related cases of C tropicalis candidemia among patients with AML following a period of neutropenia, who had erythematous skin rash as a first manifesting sign of candidiasis. C tropicalis was isolated from blood and skin cultures of both patients, which were identical by pulsed‐field gel electrophoresis typing. Our systematic review of outbreaks caused by C tropicalis suggests that (a) most reported outbreaks have occurred in neonatal and adult ICUs; (b) patients who receive total parenteral therapy, antibiotics and those who have indwelling catheters and recent surgery are at high risk of infection; and (c) environmental and healthcare personnel surveillance suggest that cross‐contamination is a major risk factor. Conclusion Control of nosocomial outbreaks caused by C tropicalis should include better infection control measures, education of healthcare professionals especially working in adult and neonatal intensive care and haematology units.