Premium
Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations
Author(s) -
Taghipour Simin,
Pchelin Ivan M.,
Zarei Mahmoudabadi Ali,
Ansari Saham,
Katiraee Farzad,
Rafiei Abdollah,
Shokohi Tahereh,
Abastabar Mahdi,
Taraskina Anastasia E.,
Kermani Firoozeh,
Diba Kambiz,
NouripourSisakht Sadegh,
Najafzadeh Mohammad Javad,
Pakshir Keyvan,
Zomorodian Kamiar,
Ahmadikia Kazem,
RezaeiMatehkolaei Ali
Publication year - 2019
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12993
Subject(s) - trichophyton , genotype , dermatophyte , tinea capitis , typing , biology , veterinary medicine , medicine , genetics , microbiology and biotechnology , gene , botany , antifungal
Summary The fungi Trichophyton mentagrophytes and T interdigitale account for significant amount of dermatophytosis cases worldwide. These two dermatophytes form a species complex and have a number of ribosomal internal transcribed spacer (ITS) region genotypes, allowing simultaneous species identification and strain typing. Our aim was to describe the geographic distribution of T mentagrophytes / T interdigitale ITS region genotypes and find an association between the genotypes and clinical presentations of respective infections. We performed rDNA ITS region sequencing in 397 Iranian T mentagrophytes / T interdigitale isolates and analysed all available in GenBank entries with sequences of this kind. For the study, 515 clinical annotations were available. Statistical analysis was performed by chi‐squared test and Spearman rank correlation analysis. A total of 971 sequences belonged to genotypes with at least 10 geographic annotations and were classified on the basis of exclusive occurrence in a particular region or high relative contribution to a regional sample. We discerned Asian and Oceanian (“ KU496915 ” Type V, “ KT192500 ” Type VIII, “ KU315316 ”), European (“ FM986750 ” Type III, “ MF926358 ” Type III*, “ KT285210 ” Type VI) and cosmopolitan (“ FM986691 ” Type I, “ JX122216 ” Type II, “ KP132819 ” Type II* and “ AF170453 ” Type XXIV) genotypes. There was statistically significant difference in the ITS genotype distribution between different affected body sites. Trichophyton mentagrophytes “ KT192500 ” Type VIII correlated with tinea cruris, T mentagrophytes “ KU496915 ” Type V correlated with tinea corporis, T interdigitale “ JX122216 ” Type II correlated with tinea pedis and onychomycosis. Trichophyton mentagrophytes and T interdigitale genotypes can be associated with distinct geographic locations and particular clinical presentations.