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Molecular epidemiology and in vitro antifungal susceptibility of Trichophyton schoenleinii, agent of tinea capitis favosa
Author(s) -
Gao Yangmin,
Zhan Ping,
Hagen Ferry,
Menken Steph B. J.,
Sun Jiufeng,
RezaeiMatehkolaei Ali,
de Hoog Sybren
Publication year - 2019
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12889
Subject(s) - biology , dermatophyte , miconazole , tinea capitis , itraconazole , microbiology and biotechnology , amplified fragment length polymorphism , terbinafine , fluconazole , molecular epidemiology , genotype , genotyping , antifungal , genetic diversity , genetics , medicine , population , gene , environmental health , horticulture
Summary Trichophyton schoenleinii is an anthropophilic dermatophyte usually causing tinea favosa. Only few studies have provided data on molecular epidemiology and antifungal profiles of this fungus due to its limited prevalence after 1950s. Forty‐nine strains from Asia (n = 27), Africa (n = 10), Europe (n = 10) and from unknown regions (n = 2) were analysed with amplified fragment length polymorphism fingerprinting ( AFLP ) to reveal intraspecific genetic diversity in this dataset. Amplified fragment length polymorphism fingerprinting genotyping revealed five clusters which did not correspond to geographic origins or clinical characteristics. Additionally, in vitro antifungal susceptibility to seven antifungals was provided for all strains. Terbinafine, ketoconazole, miconazole and itraconazole proved to be the most effective drugs, followed by griseofulvin. No correlation between genotypes and differences in antifungal susceptibility was observed. It is concluded that the AFLP groups are lineages within a single species.