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Epidemiology of fungaemia in Sweden: A nationwide retrospective observational survey
Author(s) -
Klingspor Lena,
Ullberg Måns,
Rydberg Johan,
Kondori Nahid,
Serrander Lena,
Swanberg Jonas,
Nilsson Kenneth,
Jendle Bengtén Cecilia,
Johansson Marcus,
Granlund Margareta,
Törnqvist Eva,
Nyberg Anders,
Kindlund Karin,
Ygge Minna,
KartoutBoukdir Dalila,
Toepfer Michael,
Hålldin Eva,
Kahlmeter Gunnar,
Özenci Volkan
Publication year - 2018
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12816
Subject(s) - fluconazole , anidulafungin , candida krusei , candida parapsilosis , candida glabrata , microbiology and biotechnology , voriconazole , candida tropicalis , candida albicans , fungemia , biology , blood culture , epidemiology , corpus albicans , population , medicine , micafungin , antifungal , antibiotics , environmental health
Summary Objectives To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. Methods The study was a retrospective, observational nationwide laboratory‐based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. Results In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005‐2006) to 4.7/100 000 population/year (2015‐2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%) , Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non‐ albicans species other than C. glabrata and C. krusei . Resistance to voriconazole was rare, except for C. glabrata , C. krusei and C. tropicalis . Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B. Conclusions We report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10‐year period.