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Five‐year profile of candidaemia at an Indian trauma centre: High rates of Candida auris blood stream infections
Author(s) -
Mathur Purva,
Hasan Fahmi,
Singh Pradeep K.,
Malhotra Rajesh,
Walia Kamini,
Chowdhary Anuradha
Publication year - 2018
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12790
Subject(s) - candida auris , broth microdilution , candida tropicalis , candida parapsilosis , microbiology and biotechnology , biology , candida albicans , antifungal , medicine , minimum inhibitory concentration , antibiotics
Summary Candidaemia is a potentially fatal infection with varied distribution of Candida species and their antifungal susceptibility profiles. The recent emergence of Candida auris in invasive candidiasis is a cause for concern. This study describes the profile of candidaemia at an Indian tertiary care hospital and reports the emergence of C. auris . All patients diagnosed with candidaemia between 2012 and 2017 were studied. The isolates were identified using conventional methods, VITEK 2 and MALDI ‐ TOF MS . The isolates not identified by MALDI ‐ TOF were sequenced. Antifungal susceptibility testing was done by the CLSI broth microdilution method and VITEK 2. A total of 114 isolates of Candida species were analysed. Candida tropicalis (39.4%) was the most common species, followed by C. auris (17.5%), C. albicans (14%) and C. parapsilosis (11.4%). Notably, Diutina mesorugosa isolates (n = 10) were not identified by MALDI ‐ TOF and were confirmed by sequencing. Furthermore, 45% (n = 9) C. auris strains exhibited low MIC s of FLU (0.05‐4 μg/mL) and the remaining 55% (n = 11) isolates had high MIC s ≥ 64 μg/mL. Also, D. mesorugosa exhibited high MIC s of FLU (32 μg/mL) in 2 isolates. A high rate of errors in antifungal susceptibility was noted with the VITEK 2 as compared to the CLSI method. Candida auris was the second most prevalent species causing candidaemia warranting infection control practices to be strengthened to prevent its spread.