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Fungal infections in patients with inflammatory bowel disease: A systematic review
Author(s) -
Stamatiades George A.,
Ioannou Petros,
Petrikkos George,
Tsioutis Constantinos
Publication year - 2018
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12753
Subject(s) - inflammatory bowel disease , medicine , disease , systematic review , candida infections , inflammatory bowel diseases , intensive care medicine , immunology , medline , antifungal , dermatology , biology , biochemistry
Summary Background Despite reports of fungal infections in patients with inflammatory bowel disease ( IBD ), their clinical and microbiological characteristics remain unknown. Objectives The aim of this systematic review was to examine all available evidence regarding fungal infections in patients with IBD . Methods Systematic search of PubMed (through 27 May 2017) for studies providing data on clinical, microbiological, treatment and outcome data of fungal infections in patients with IBD . The primary study outcome was to record the most common fungal species in patients with IBD . Secondary outcomes were classified into 3 categories: (i) characteristics of fungal infections; (ii) data on IBD and (iii) treatment and outcomes of fungal infections in patients with IBD . Results Fourteen studies with data on 1524 patients were included in final analysis. The most common fungal infections in patients with IBD were caused by Candida species (903 infections); the most commonly reported site of Candida infection was the gastrointestinal tract. Available evidence shows that most fungal infections occur within 12 months of IBD treatment and within 6 months when anti‐ TNF a agents are used. Conclusions This systematic review thoroughly describes fungal infections in patients with IBD and provides important information for the early detection and management of these infections.