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Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation
Author(s) -
Hoffmann Wesley J.,
McHardy Ian,
Thompson George R.
Publication year - 2018
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12749
Subject(s) - hypokalemia , itraconazole , metabolic alkalosis , medicine , endocrinology , adverse effect , mineralocorticoid , pharmacology , aldosterone , dermatology , antifungal
Summary We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β‐hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.