Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation | Zendy

Hoffmann Wesley J. | Zendy; McHardy Ian | Zendy; Thompson George R. | Zendy

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Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Author(s) -

Hoffmann Wesley J.,

McHardy Ian,

Thompson George R.

Publication year - 2018

Publication title -

mycoses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.13

H-Index - 69

eISSN - 1439-0507

pISSN - 0933-7407

DOI - 10.1111/myc.12749

Subject(s) - hypokalemia , itraconazole , metabolic alkalosis , medicine , endocrinology , adverse effect , mineralocorticoid , pharmacology , aldosterone , dermatology , antifungal

Summary We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β‐hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

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