Clinical evaluation of the newly formatted lateral‐flow device for invasive pulmonary aspergillosis | Zendy

Hoenigl Martin | Zendy; Eigl Susanne | Zendy; Heldt Sven | Zendy; Duettmann Wiebke | Zendy; Thornton Christopher | Zendy; Prattes Juergen | Zendy

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Clinical evaluation of the newly formatted lateral‐flow device for invasive pulmonary aspergillosis

Author(s) -

Hoenigl Martin,

Eigl Susanne,

Heldt Sven,

Duettmann Wiebke,

Thornton Christopher,

Prattes Juergen

Publication year - 2018

Publication title -

mycoses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.13

H-Index - 69

eISSN - 1439-0507

pISSN - 0933-7407

DOI - 10.1111/myc.12704

Subject(s) - pulmonary aspergillosis , aspergillosis , medicine , aspergillus , diagnostic accuracy , microbiology and biotechnology , biology , immunology

Summary The study evaluated the newly formatted Aspergillus ‐specific lateral‐flow‐device ( LFD ), and compared its performance to the original prototype “old” LFD test using BALF samples from 28 patients (14 patients with probable/proven invasive pulmonary aspergillosis [ IPA ] and 14 patients with no evidence for IPA ). A total of 10/14 (71%) of BALF samples from patients with probable/proven IPA resulted positive with the new LFD , including 8/9 with true‐positive and 2/5 with false‐negative results with the old LFD . All 14 samples from patients without IPA resulted negative with the new LFD ; specificity of the new LFD was significantly improved compared to the old LFD .

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