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Candida bloodstream infections in Serbia: First multicentre report of a national prospective observational survey in intensive care units
Author(s) -
Arsić Arsenijević Valentina,
Otašević Suzana,
Janić Dragana,
Minić Predrag,
Matijašević Jovan,
Medić Deana,
Savić Ivanka,
Delić Snežana,
Nestorović Laban Suzana,
Vasiljević Zorica,
Hadnadjev Mirjana
Publication year - 2018
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/myc.12700
Subject(s) - medicine , fluconazole , intensive care , candida parapsilosis , incidence (geometry) , epidemiology , candida albicans , pediatrics , intensive care medicine , microbiology and biotechnology , antifungal , biology , physics , dermatology , optics
Summary Candida bloodstream infections ( BSI ) are a significant cause of mortality in intensive care units ( ICU ), hereof the prospective 12‐months (2014‐2015) hospital‐ and laboratory‐based survey was performed at the Serbian National Reference Medical Mycology Laboratory ( NRMML ). Candida identification was done by a matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry and a susceptibility test, according to the Clinical and Laboratory Standards Institute methodology. Among nine centres (265 beds; 10 820 patient admissions), four neonatal/paediatric ( NICU / PICU s) and five adult centres ( ICU s) participated, representing 89 beds and 3446 patient admissions, 166 beds and 7347 patient admissions respectively. The NRMML received 43 isolates, 17 from NICU / PICU s and 26 from adult ICU s. C. albicans dominated highly in NICU / PICU s (~71%), whereas C. albicans and C. parapsilosis were equally distributed within adults (46%, each), both accounting for ~90% of received isolates. The resistance to itraconazole and flucytosine were 25% and 2.4% respectively. In addition, the 2 C . albicans were azole cross‐resistant (4.6%). The overall incidence of Candida BSI was ~3.97 cases/1000 patient admissions (4.93 in NICU / PICU and 3.53 in adult ICU ). The 30‐day mortality was ~37%, most associated with C. tropicalis and C. glabrata BSI . Data from this national survey may contribute to improving the Balkan and Mediterranean region epidemiology of Candida BSI within ICU s.